Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each d...

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Bibliographic Details
Main Authors:	Gaulton, KJ, Ferreira, T, Lee, Y, Raimondo, A, Mägi, R, Mahajan, A, Rayner, N, Morris, A, Thomsen, S, van de Bunt, M, Beer, N, Gloyn, A, Lindgren, C, Robertson, N, Trakalo, J, Wiltshire, S, Ingelsson, E, Donnelly, P, Rundle, J, Groves, C, Owen, K, Reschen, M, Chalisey, A, O'Callaghan, C, McCarthy, M, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM)
Format:	Journal article
Language:	English
Published:	Nature Publishing Group 2015

Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

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