The unusual bifunctional catalysis of epimerization and desaturation by carbapenem synthase.

The unusual bifunctional catalysis of epimerization and desaturation by carbapenem synthase.

High-level ab initio calculations have been used to study the mechanism for the conversion of (3S,5S)-carbapenam to the biologically active beta-lactam antibiotic, (5R)-carbapenem, catalyzed by carbapenem synthase. This process involves epimerization at C5 and desaturation at C2/C3. Our calculations...

书目详细资料
Main Authors:	Topf, M, Sandala, G, Smith, D, Schofield, C, Easton, C, Radom, L
格式:	Journal article
语言:	English
出版:	2004

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