Discovery and characterization of GSK2801, a selective chemical probe for the bromodomains BAZ2A and BAZ2B

Discovery and characterization of GSK2801, a selective chemical probe for the bromodomains BAZ2A and BAZ2B

<p>Bromodomains are acetyl-lysine specific protein interaction domains that have recently emerged as a new target class for the development of inhibitors that modulate gene transcription. The two closely related bromodomain containing proteins BAZ2A and BAZ2B constitute the central scaffolding...

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Bibliographic Details
Main Authors: Chen, P, Chaikuad, A, Bamborough, P, Bantscheff, M, Bountra, C, Chung, C, Fedorov, O, Grandi, P, Jung, D, Lesniak, R, Lindon, M, Müller, S, Philpott, M, Prinjha, R, Rogers, C, Selenski, C, Tallant, C, Werner, T, Willson, T, Knapp, S, Drewry, D
Format: Journal article
Language:English
Published: American Chemical Society 2015

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