Exhausted CD4+ T cells during malaria exhibit reduced mTORc1 activity correlated with loss of T-bet expression

CD4<sup>+</sup> T cell functional inhibition (exhaustion) is a hallmark of malaria and correlates with impaired parasite control and infection chronicity. However, the mechanisms of CD4<sup>+</sup> T cell exhaustion are still poorly understood....

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Detaylı Bibliyografya
Asıl Yazarlar: Villegas-Mendez, A, Khandelwal, G, McGowan, LM, Dookie, RS, Haley, MJ, George, C, Sims, D, Lord, GM, Sinclair, LV, Jenner, RG, Couper, KN
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: American Association of Immunologists 2020