Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes

Библиографические подробности
Главные авторы:	Groves, C, Zeggini, E, Minton, J, Frayling, T, Weedon, M, Rayner, N, Hitman, G, Walker, M, Wiltshire, S, Hattersley, A, McCarthy, M
Формат:	Conference item
Опубликовано:	2006

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
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Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight
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Large-scale association studies of candidate genes and their interactions in Type 2 diabetes
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Common variation in the LMNA gene increases susceptibility to type 2 diabetes
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Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.
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TCF7L2: the biggest story in diabetes genetics since HLA?
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Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.
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Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.
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Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
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No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.
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Studies of genome-wide association data support a genetic overlap between type 2 diabetes and prostate cancer
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Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.
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Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
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Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
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Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
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A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
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Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes.
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Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
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Genome-wide search for multiple loci in type 2 diabetes
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Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
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The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
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Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.
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Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans.
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Biological pathway analysis for type 2 diabetes using genome-wide association data
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Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
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Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.
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Genome-wide association scan allowing for epistasis in type 2 diabetes.
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Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.
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Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
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Assessment of the role of genetic variation in the transient neonatal diabetes (TNDM) region on chromosome 6q24 in type 2 diabetes: a comparative genomic and haplotype approach
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Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
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Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
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An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets.
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Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.
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Pharmacogenetics in Type 2 diabetes: variation in TCF7L2 influences response to sulphonylureas
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Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
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A powerful approach to sub-phenotype analysis in population-based genetic association studies.
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Extended analysis of genome-wide scans provides clues about novel common and rare susceptibility loci for type 2 diabetes
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Large scale case-control and family-based analyses of TCF7L2 variants in &gt; 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes

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Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes