Oligomerization-driven avidity correlates with SARS-CoV-2 cellular binding and inhibition

Cellular processes are controlled by the thermodynamics of the underlying biomolecular interactions. Frequently, structural investigations use one monomeric binding partner, while ensemble measurements of binding affinities generally yield one affinity representative of a 1:1 interaction, despite th...

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Autors principals: Asor, R, Olerinyova, A, Burnap, SA, Kushwah, M, Soltermann, F, Rudden, LSP, Hensen, M, Vasiljevic, S, Brun, J, Hill, M, Chang, L, Dejnirattisa, W, Supasa, P, Mogkolsapaya, J, Zhou, D, Stuart, D, Screaton, GR, Degiacomi, M, Zitzmann, N, Benesch, J, Struwe, W, Kukura, P
Format: Journal article
Idioma:English
Publicat: National Academy of Sciences 2024