Oligomerization-driven avidity correlates with SARS-CoV-2 cellular binding and inhibition

Oligomerization-driven avidity correlates with SARS-CoV-2 cellular binding and inhibition

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Cellular processes are controlled by the thermodynamics of the underlying biomolecular interactions. Frequently, structural investigations use one monomeric binding partner, while ensemble measurements of binding affinities generally yield one affinity representative of a 1:1 interaction, despite th...

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Main Authors: Asor, R, Olerinyova, A, Burnap, SA, Kushwah, M, Soltermann, F, Rudden, LSP, Hensen, M, Vasiljevic, S, Brun, J, Hill, M, Chang, L, Dejnirattisa, W, Supasa, P, Mogkolsapaya, J, Zhou, D, Stuart, D, Screaton, GR, Degiacomi, M, Zitzmann, N, Benesch, J, Struwe, W, Kukura, P
פורמט: Journal article
שפה:English
יצא לאור: National Academy of Sciences 2024

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