Oligomerization-driven avidity correlates with SARS-CoV-2 cellular binding and inhibition

Cellular processes are controlled by the thermodynamics of the underlying biomolecular interactions. Frequently, structural investigations use one monomeric binding partner, while ensemble measurements of binding affinities generally yield one affinity representative of a 1:1 interaction, despite th...

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Bibliografische gegevens
Hoofdauteurs: Asor, R, Olerinyova, A, Burnap, SA, Kushwah, M, Soltermann, F, Rudden, LSP, Hensen, M, Vasiljevic, S, Brun, J, Hill, M, Chang, L, Dejnirattisa, W, Supasa, P, Mogkolsapaya, J, Zhou, D, Stuart, D, Screaton, GR, Degiacomi, M, Zitzmann, N, Benesch, J, Struwe, W, Kukura, P
Formaat: Journal article
Taal:English
Gepubliceerd in: National Academy of Sciences 2024