Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions.

Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions.

Small molecules which can mimic the key structural facets of protein secondary structure, in particular the α-helix, β-strand, and β-sheet, have been shown to be potent disruptors of protein-protein interactions. Researchers have recently taken the organizational imitation of protein secondary struc...

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Príomhchruthaitheoirí: Adler, M, Jamieson, A, Hamilton, A
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2011
Cur síos
Achoimre:Small molecules which can mimic the key structural facets of protein secondary structure, in particular the α-helix, β-strand, and β-sheet, have been shown to be potent disruptors of protein-protein interactions. Researchers have recently taken the organizational imitation of protein secondary structure to a new level by using intramolecular hydrogen bonds as stabilizing forces in these small molecule mimetics. The inclusion of these interactions invokes a conformational bias of the system, allowing for greater control of the appearance, and thus often function, of these molecules by design.

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