Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions.
Small molecules which can mimic the key structural facets of protein secondary structure, in particular the α-helix, β-strand, and β-sheet, have been shown to be potent disruptors of protein-protein interactions. Researchers have recently taken the organizational imitation of protein secondary struc...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797088873463939072 |
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| author | Adler, M Jamieson, A Hamilton, A |
| author_facet | Adler, M Jamieson, A Hamilton, A |
| author_sort | Adler, M |
| collection | OXFORD |
| description | Small molecules which can mimic the key structural facets of protein secondary structure, in particular the α-helix, β-strand, and β-sheet, have been shown to be potent disruptors of protein-protein interactions. Researchers have recently taken the organizational imitation of protein secondary structure to a new level by using intramolecular hydrogen bonds as stabilizing forces in these small molecule mimetics. The inclusion of these interactions invokes a conformational bias of the system, allowing for greater control of the appearance, and thus often function, of these molecules by design. |
| first_indexed | 2024-03-07T02:56:21Z |
| format | Journal article |
| id | oxford-uuid:af6ad5e1-847f-427a-acd5-039e74f011d0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:56:21Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:af6ad5e1-847f-427a-acd5-039e74f011d02022-03-27T03:49:26ZHydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:af6ad5e1-847f-427a-acd5-039e74f011d0EnglishSymplectic Elements at Oxford2011Adler, MJamieson, AHamilton, ASmall molecules which can mimic the key structural facets of protein secondary structure, in particular the α-helix, β-strand, and β-sheet, have been shown to be potent disruptors of protein-protein interactions. Researchers have recently taken the organizational imitation of protein secondary structure to a new level by using intramolecular hydrogen bonds as stabilizing forces in these small molecule mimetics. The inclusion of these interactions invokes a conformational bias of the system, allowing for greater control of the appearance, and thus often function, of these molecules by design. |
| spellingShingle | Adler, M Jamieson, A Hamilton, A Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. |
| title | Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. |
| title_full | Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. |
| title_fullStr | Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. |
| title_full_unstemmed | Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. |
| title_short | Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. |
| title_sort | hydrogen bonded synthetic mimics of protein secondary structure as disruptors of protein protein interactions |
| work_keys_str_mv | AT adlerm hydrogenbondedsyntheticmimicsofproteinsecondarystructureasdisruptorsofproteinproteininteractions AT jamiesona hydrogenbondedsyntheticmimicsofproteinsecondarystructureasdisruptorsofproteinproteininteractions AT hamiltona hydrogenbondedsyntheticmimicsofproteinsecondarystructureasdisruptorsofproteinproteininteractions |