Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1.

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected CEM cell cultures with escalating concentrations of the quinoxaline S-2720 resulted in an ordered appearance of single and multiple mutant virus strains that gradually became resistant to the quinoxaline and other nonnucleoside revers...

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Detalhes bibliográficos
Main Authors: Pelemans, H, Esnouf, R, Dunkler, A, Parniak, M, Vandamme, A, Karlsson, A, De Clercq, E, Kleim, J, Balzarini, J
Formato: Journal article
Idioma:English
Publicado em: 1997