Comparison of heterosubtypic protection in ferrets and pigs induced by a single-cycle influenza vaccine
Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a mi...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Association of Immunologists
2018
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| _version_ | 1797088923172732928 |
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| author | Holzer, B Morgan, S Matsuoka, Y Edmans, M Salguero, F Everett, H Brookes, S Porter, E Macloughlin, R Charleston, B Subbarao, K Townsend, A Tchilian, E |
| author_facet | Holzer, B Morgan, S Matsuoka, Y Edmans, M Salguero, F Everett, H Brookes, S Porter, E Macloughlin, R Charleston, B Subbarao, K Townsend, A Tchilian, E |
| author_sort | Holzer, B |
| collection | OXFORD |
| description | Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a minimal Ab response to hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs and ferrets from heterosubtypic H1N1 influenza challenge. Aerosol administration of S-FLU to pigs induced lung tissue-resident memory T cells and reduced lung pathology but not the viral load. In contrast, in ferrets, S-FLU reduced viral replication and aerosol transmission. Our data show that S-FLU has different protective efficacy in pigs and ferrets, and that in the absence of Ab, lung T cell immunity can reduce disease severity without reducing challenge viral replication. |
| first_indexed | 2024-03-07T02:57:03Z |
| format | Journal article |
| id | oxford-uuid:afadabf3-fe4e-496f-ace8-1760334deef8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:57:03Z |
| publishDate | 2018 |
| publisher | American Association of Immunologists |
| record_format | dspace |
| spelling | oxford-uuid:afadabf3-fe4e-496f-ace8-1760334deef82022-03-27T03:51:04ZComparison of heterosubtypic protection in ferrets and pigs induced by a single-cycle influenza vaccineJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:afadabf3-fe4e-496f-ace8-1760334deef8EnglishSymplectic Elements at OxfordAmerican Association of Immunologists2018Holzer, BMorgan, SMatsuoka, YEdmans, MSalguero, FEverett, HBrookes, SPorter, EMacloughlin, RCharleston, BSubbarao, KTownsend, ATchilian, EInfluenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a minimal Ab response to hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs and ferrets from heterosubtypic H1N1 influenza challenge. Aerosol administration of S-FLU to pigs induced lung tissue-resident memory T cells and reduced lung pathology but not the viral load. In contrast, in ferrets, S-FLU reduced viral replication and aerosol transmission. Our data show that S-FLU has different protective efficacy in pigs and ferrets, and that in the absence of Ab, lung T cell immunity can reduce disease severity without reducing challenge viral replication. |
| spellingShingle | Holzer, B Morgan, S Matsuoka, Y Edmans, M Salguero, F Everett, H Brookes, S Porter, E Macloughlin, R Charleston, B Subbarao, K Townsend, A Tchilian, E Comparison of heterosubtypic protection in ferrets and pigs induced by a single-cycle influenza vaccine |
| title | Comparison of heterosubtypic protection in ferrets and pigs induced by a single-cycle influenza vaccine |
| title_full | Comparison of heterosubtypic protection in ferrets and pigs induced by a single-cycle influenza vaccine |
| title_fullStr | Comparison of heterosubtypic protection in ferrets and pigs induced by a single-cycle influenza vaccine |
| title_full_unstemmed | Comparison of heterosubtypic protection in ferrets and pigs induced by a single-cycle influenza vaccine |
| title_short | Comparison of heterosubtypic protection in ferrets and pigs induced by a single-cycle influenza vaccine |
| title_sort | comparison of heterosubtypic protection in ferrets and pigs induced by a single cycle influenza vaccine |
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