Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.

Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.

RATIONALE: Hypoxia followed by reoxygenation promotes inflammation by activating nuclear factor κB transcription factors in endothelial cells (ECs). This process involves modification of the signaling intermediary tumor necrosis factor receptor-associated factor 6 with polyubiquitin chains. Thus, ce...

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Detalhes bibliográficos
Principais autores: Luong, L, Fragiadaki, M, Smith, J, Boyle, J, Lutz, J, Dean, J, Harten, S, Ashcroft, M, Walmsley, SR, Haskard, DO, Maxwell, P, Walczak, H, Pusey, C, Evans, P
Formato: Journal article
Idioma:English
Publicado em: 2013

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