The anti-malarial drug atovaquone potentiates platinum-mediated cancer cell death by increasing oxidative stress
Platinum chemotherapies are highly effective cytotoxic agents but often induce resistance when used as monotherapies. Combinatorial strategies limit this risk and provide effective treatment options for many cancers. Here, we repurpose atovaquone (ATQ), a well-tolerated & FDA-approved anti-malar...
Үндсэн зохиолчид: | Coates, JTT, Rodriguez-Berriguete, G, Puliyadi, R, Ashton, T, Prevo, R, Wing, A, Granata, G, Pirovano, G, McKenna, GW, Higgins, GS |
---|---|
Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
Springer Nature
2020
|
Нөхцлүүд: |
Ижил төстэй зүйлс
Ижил төстэй зүйлс
-
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
-н: Ashton, T, зэрэг
Хэвлэсэн: (2016) -
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
-н: Thomas M. Ashton, зэрэг
Хэвлэсэн: (2016-07-01) -
CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner
-н: Prevo, R, зэрэг
Хэвлэсэн: (2018) -
Investigating the role of the anti-malarial drug Atovaquone in anti-cancer therapy
-н: Watson, D, зэрэг
Хэвлэсэн: (2019) -
Antitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models
-н: Gonzalo Rodriguez-Berriguete, зэрэг
Хэвлэсэн: (2024-01-01)