Structural basis of prolyl hydroxylase domain inhibition by Molidustat

Human prolyl-hydroxylases (PHDs) are hypoxia-sensing 2-oxoglutarate (2OG) oxygenases, catalysis by which suppresses the transcription of hypoxia-inducible factor target genes. PHD inhibition enables the treatment of anaemia/ischaemia-related disease. The PHD inhibitor Molidustat is approved for the...

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Автори: Figg, WD, McDonough, MA, Chowdhury, R, Nakashima, Y, Zhang, Z, Holt-Martyn, JP, Krajnc, A, Schofield, CJ
Формат: Journal article
Мова:English
Опубліковано: Wiley 2021