Structural basis of prolyl hydroxylase domain inhibition by Molidustat

Structural basis of prolyl hydroxylase domain inhibition by Molidustat

Human prolyl-hydroxylases (PHDs) are hypoxia-sensing 2-oxoglutarate (2OG) oxygenases, catalysis by which suppresses the transcription of hypoxia-inducible factor target genes. PHD inhibition enables the treatment of anaemia/ischaemia-related disease. The PHD inhibitor Molidustat is approved for the...

Bibliografiset tiedot
Päätekijät:	Figg, WD, McDonough, MA, Chowdhury, R, Nakashima, Y, Zhang, Z, Holt-Martyn, JP, Krajnc, A, Schofield, CJ
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	Wiley 2021

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