Prospective study of cancer in patients with hypogammaglobulinaemia.

Among 377 patients with primary hypogammaglobulinaemia, mainly common variable immunodeficiency (CVID), 316 patients survived the first 2 years after diagnosis and were the subject of a study of cancer incidence. Among the 220 patients with CVID, there was a 5-fold increase of cancer due mainly to l...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Kinlen, L, Webster, A, Bird, A, Haile, R, Peto, J, Soothill, J, Thompson, R
التنسيق: Journal article
اللغة:English
منشور في: 1985
الوصف
الملخص:Among 377 patients with primary hypogammaglobulinaemia, mainly common variable immunodeficiency (CVID), 316 patients survived the first 2 years after diagnosis and were the subject of a study of cancer incidence. Among the 220 patients with CVID, there was a 5-fold increase of cancer due mainly to large excesses of stomach cancer (47-fold) and lymphomas (30-fold). The excess of stomach cancer is probably related to the high frequency of achlorhydria in CVID. 3 of the 7 patients with stomach cancer and CVID survived for 5 years or longer.