11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.

AIMS/HYPOTHESIS: Exposure to excess glucocorticoid is associated with pancreatic beta cell damage and decreased glucose-stimulated insulin secretion (GSIS). Inactive glucocorticoids (cortisone, 11-dehydrocorticosterone) are converted to active cortisol and corticosterone by 11beta-hydroxysteroid de...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Swali, A, Walker, E, Lavery, G, Tomlinson, J, Stewart, P
Format: Journal article
Sprache:English
Veröffentlicht: 2008