Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.

Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.

BACKGROUND: Pulmonary hypertension is a fatal disease characterized by vasoconstriction and vascular remodeling. Loss of endothelial nitric oxide bioavailability is implicated in pulmonary hypertension pathogenesis. Recent evidence suggests that the cofactor tetrahydrobiopterin (BH4) is an importan...

Полное описание

Библиографические подробности
Главные авторы:	Khoo, J, Zhao, L, Alp, N, Bendall, J, Nicoli, T, Rockett, K, Wilkins, MR, Channon, K
Формат:	Journal article
Язык:	English
Опубликовано:	2005

Схожие документы

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
по: Khoo, J, и др.
Опубликовано: (2004)

Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation
по: Khoo, J, и др.
Опубликовано: (2005)

Tetrahydrobiopterin deficiency causes pulmonary hypertension: Effects on lung superoxide levels, hypoxic pulmonary vasoconstriction and vascular remodelling
по: Khoo, J, и др.
Опубликовано: (2004)

Endothelial tetrahydrobiopterin regulates eNOS coupling/uncoupling independent of vascular disease: Insights from targeted transgenic models
по: Bendall, J, и др.
Опубликовано: (2004)

Endothelial tetrahydrobiopterin (BH4) regulates eNOS coupling in vivo: Functional effects of BH4-eNOS stoichiometry in endothelial targeted transgenic mice
по: Bendall, J, и др.
Опубликовано: (2005)

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
по: Bendall, J, и др.
Опубликовано: (2004)

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
по: Alp, N, и др.
Опубликовано: (2003)

GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension
по: Khoo, J, и др.
Опубликовано: (2004)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
по: Chuaiphichai, S, и др.
Опубликовано: (2014)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
по: Chuaiphichai, S, и др.
Опубликовано: (2014)

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
по: Bendall, J, и др.
Опубликовано: (2005)

Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.
по: Khoo, J, и др.
Опубликовано: (2004)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
по: Alp, N, и др.
Опубликовано: (2004)

303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
по: Chuaiphichai, S, и др.
Опубликовано: (2014)

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
по: Alp, N, и др.
Опубликовано: (2003)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
по: Alp, N, и др.
Опубликовано: (2004)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
по: Cai, S, и др.
Опубликовано: (2005)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
по: Khoo, J, и др.
Опубликовано: (2005)

Increased endothelial tetrahydrobiopterin levels in GTPCH-transgenic mice
по: Alp, N, и др.
Опубликовано: (2002)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
по: Cai, S, и др.
Опубликовано: (2004)

Nitric oxide bioactivity in ApoE -/- mice is maintained by increased endothelial tetrahydrobiopterin synthesis via targeted GTP cyclohydrolase-1 over-expression
по: Alp, N, и др.
Опубликовано: (2003)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft accelerated atherosclerosis in apolipoprotein E-knockout mice
по: Ali, Z, и др.
Опубликовано: (2006)

Tetrahydrobiopterin deficiency increases susceptibility to atherosclerosis
по: Khoo, J, и др.
Опубликовано: (2005)

Increased endothelial tetrahydrobiopterin levels by GTPCH over expression in transgenic mice prevents diabetic endothelial dysfunction
по: Alp, N, и др.
Опубликовано: (2003)

Endothelial cell tetrahydrobiopterin: going with the flow.
по: De Bono, J, и др.
Опубликовано: (2007)

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
по: Alp, N, и др.
Опубликовано: (2004)

Increased endothelial tetrahydrobiopterin reduces in stent stenosis in apolipoprotein E-knockout mice
по: Ali, Z, и др.
Опубликовано: (2007)

Tetrahydrobiopterin regulates vagal control of heart rate
по: Adlam, D, и др.
Опубликовано: (2005)

Tetrahydrobiopterin in cardiovascular health and disease.
по: Bendall, J, и др.
Опубликовано: (2014)

Tetrahydrobiopterin (BH4) Improves Endothelial Cell Survival After Vascular Injury
по: Rinze, R, и др.
Опубликовано: (2008)

Increased Endothelial Tetrahydrobiopterin Reduces In Stent Stenosis in Apolipoprotein E-Knockout Mice
по: Ali, Z, и др.
Опубликовано: (2011)

CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
по: Ali, Z, и др.
Опубликовано: (2008)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
по: Crabtree, M, и др.
Опубликовано: (2011)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
по: Crabtree, M, и др.
Опубликовано: (2011)

Tetrahydrobiopterin: a vascular redox target to improve endothelial function.
по: Channon, K
Опубликовано: (2012)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
по: Channon, K
Опубликовано: (2004)

A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in vascular resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice
по: Chuaiphichai, S, и др.
Опубликовано: (2017)

Correction of tetrahydrobiopterin deficiency - Implications for dopa responsive dystonia and other inherited disorders of tetrahydrobiopterin metabolism
по: Heales, S, и др.
Опубликовано: (2005)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice
по: Ali, Z, и др.
Опубликовано: (2005)

A Novel Role for Endothelial Tetrahydrobiopterin in Mitochondrial Redox Balance
по: Bailey, J, и др.
Опубликовано: (2017)