Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.

Pivotal role for endothelial tetrahydrobiopterin in pulmonary hypertension.

BACKGROUND: Pulmonary hypertension is a fatal disease characterized by vasoconstriction and vascular remodeling. Loss of endothelial nitric oxide bioavailability is implicated in pulmonary hypertension pathogenesis. Recent evidence suggests that the cofactor tetrahydrobiopterin (BH4) is an importan...

Detaylı Bibliyografya
Asıl Yazarlar:	Khoo, J, Zhao, L, Alp, N, Bendall, J, Nicoli, T, Rockett, K, Wilkins, MR, Channon, K
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	2005

Benzer Materyaller

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
Yazar:: Khoo, J, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Prevention of hypoxia-induced pulmonary hypertension and vascular remodelling by targeting endothelial tetrahydrobiopterin-dependent nitric oxide synthase regulation
Yazar:: Khoo, J, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Tetrahydrobiopterin deficiency causes pulmonary hypertension: Effects on lung superoxide levels, hypoxic pulmonary vasoconstriction and vascular remodelling
Yazar:: Khoo, J, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Endothelial tetrahydrobiopterin regulates eNOS coupling/uncoupling independent of vascular disease: Insights from targeted transgenic models
Yazar:: Bendall, J, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Endothelial tetrahydrobiopterin (BH4) regulates eNOS coupling in vivo: Functional effects of BH4-eNOS stoichiometry in endothelial targeted transgenic mice
Yazar:: Bendall, J, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
Yazar:: Bendall, J, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
Yazar:: Alp, N, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension
Yazar:: Khoo, J, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Yazar:: Chuaiphichai, S, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
Yazar:: Chuaiphichai, S, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
Yazar:: Bendall, J, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse.
Yazar:: Khoo, J, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
Yazar:: Alp, N, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Yazar:: Chuaiphichai, S, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
Yazar:: Alp, N, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
Yazar:: Alp, N, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
Yazar:: Cai, S, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
Yazar:: Khoo, J, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Increased endothelial tetrahydrobiopterin levels in GTPCH-transgenic mice
Yazar:: Alp, N, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
Yazar:: Cai, S, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Nitric oxide bioactivity in ApoE -/- mice is maintained by increased endothelial tetrahydrobiopterin synthesis via targeted GTP cyclohydrolase-1 over-expression
Yazar:: Alp, N, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft accelerated atherosclerosis in apolipoprotein E-knockout mice
Yazar:: Ali, Z, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Tetrahydrobiopterin deficiency increases susceptibility to atherosclerosis
Yazar:: Khoo, J, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Increased endothelial tetrahydrobiopterin levels by GTPCH over expression in transgenic mice prevents diabetic endothelial dysfunction
Yazar:: Alp, N, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Endothelial cell tetrahydrobiopterin: going with the flow.
Yazar:: De Bono, J, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
Yazar:: Alp, N, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Increased endothelial tetrahydrobiopterin reduces in stent stenosis in apolipoprotein E-knockout mice
Yazar:: Ali, Z, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Tetrahydrobiopterin regulates vagal control of heart rate
Yazar:: Adlam, D, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Tetrahydrobiopterin in cardiovascular health and disease.
Yazar:: Bendall, J, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

Tetrahydrobiopterin (BH4) Improves Endothelial Cell Survival After Vascular Injury
Yazar:: Rinze, R, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Increased Endothelial Tetrahydrobiopterin Reduces In Stent Stenosis in Apolipoprotein E-Knockout Mice
Yazar:: Ali, Z, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
Yazar:: Ali, Z, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
Yazar:: Crabtree, M, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
Yazar:: Crabtree, M, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

Tetrahydrobiopterin: a vascular redox target to improve endothelial function.
Yazar:: Channon, K
Baskı/Yayın Bilgisi: (2012)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
Yazar:: Channon, K
Baskı/Yayın Bilgisi: (2004)

A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in vascular resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice
Yazar:: Chuaiphichai, S, ve diğerleri
Baskı/Yayın Bilgisi: (2017)

Correction of tetrahydrobiopterin deficiency - Implications for dopa responsive dystonia and other inherited disorders of tetrahydrobiopterin metabolism
Yazar:: Heales, S, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice
Yazar:: Ali, Z, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

A Novel Role for Endothelial Tetrahydrobiopterin in Mitochondrial Redox Balance
Yazar:: Bailey, J, ve diğerleri
Baskı/Yayın Bilgisi: (2017)