The HIF pathway: implications for patterns of gene expression in cancer.

The HIF pathway: implications for patterns of gene expression in cancer.

Regulation of the growth and metabolism of large organisms is tightly constrained by the need for precise oxygen homeostasis. Work on control of the haematopoietic growth factor erythropoietin has led to the recognition of a widespread transcriptional response to hypoxia which provides insights into...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Wykoff, C, Pugh, C, Harris, A, Maxwell, P, Ratcliffe, P
التنسيق:	Journal article
اللغة:	English
منشور في:	2001

مواد مشابهة

Activation of the HIF pathway in cancer.
حسب: Maxwell, P, وآخرون
منشور في: (2001)

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling.
حسب: Wykoff, C, وآخرون
منشور في: (2000)

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
حسب: Talks, K, وآخرون
منشور في: (2000)

Targeting tumors through the HIF system.
حسب: Ratcliffe, P, وآخرون
منشور في: (2000)

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
حسب: Mole, D, وآخرون
منشور في: (2001)

The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.
حسب: Maxwell, P, وآخرون
منشور في: (2001)

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
حسب: Wood, S, وآخرون
منشور في: (1998)

Hypoxia and HIF pathway in cancer and the placenta
حسب: Macklin, P, وآخرون
منشور في: (2017)

Regulation of angiogenesis by hypoxia: role of the HIF system.
حسب: Pugh, C, وآخرون
منشور في: (2003)

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
حسب: Mole, D, وآخرون
منشور في: (2002)

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.
حسب: Pugh, C, وآخرون
منشور في: (2003)

The HIF hydroxylase pathway and the tumour microenvironment
حسب: Ratcliffe, P
منشور في: (2008)

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
حسب: Raval, R, وآخرون
منشور في: (2005)

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.
حسب: Mandriota, S, وآخرون
منشور في: (2002)

Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene.
حسب: Wykoff, C, وآخرون
منشور في: (2004)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
حسب: Willam, C, وآخرون
منشور في: (2006)

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
حسب: Elvidge, G, وآخرون
منشور في: (2006)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
حسب: McNeill, L, وآخرون
منشور في: (2002)

Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression.
حسب: Ratcliffe, P, وآخرون
منشور في: (1998)

Oxygen mediated gene regulation
حسب: Pugh, C, وآخرون
منشور في: (2002)

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.
حسب: Wiesener, MS, وآخرون
منشور في: (2003)

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
حسب: Hon, W, وآخرون
منشور في: (2002)

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
حسب: Stolze, I, وآخرون
منشور في: (2004)

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
حسب: Kaelin, W, وآخرون
منشور في: (2008)

HIF-1 and HIF-2: working alone or together in hypoxia?
حسب: Ratcliffe, P
منشور في: (2007)

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation.
حسب: Formenti, F, وآخرون
منشور في: (2011)

Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor.
حسب: Vaux, E, وآخرون
منشور في: (2001)

Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation.
حسب: Maxwell, P, وآخرون
منشور في: (2001)

Oxygen sensing by HIF hydroxylases.
حسب: Schofield, C, وآخرون
منشور في: (2004)

Signalling hypoxia by HIF hydroxylases.
حسب: Schofield, C, وآخرون
منشور في: (2005)

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
حسب: Elkins, J, وآخرون
منشور في: (2003)

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
حسب: Wykoff, C, وآخرون
منشور في: (2000)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
حسب: Mole, D, وآخرون
منشور في: (2003)

Regulation of gene expression by oxygen levels in mammalian cells.
حسب: Pugh, C, وآخرون
منشور في: (1999)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
حسب: Tuckerman, JR, وآخرون
منشور في: (2004)

Genetic insights into the hypoxia-inducible factor (HIF) pathway.
حسب: Kiriakidis, S, وآخرون
منشور في: (2007)

Targeting the hypoxia-inducible factor (HIF) pathway in cancer.
حسب: Poon, E, وآخرون
منشور في: (2009)

Regulation of expression of the erythropoietin gene.
حسب: Maxwell, P, وآخرون
منشور في: (1998)

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression
حسب: Schödel, J, وآخرون
منشور في: (2012)

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression.
حسب: Schödel, J, وآخرون
منشور في: (2012)