Identifying the mechanisms driving pancreatic ductal adenocarcinoma stem cell characteristics using single-cell RNA-sequencing

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest human malignancies. Surgery, the only curative treatment, is precluded by the late stage at diagnosis in 80% of cases. Recurrence after surgery is common, and the disease does not respond well to chemotherapy and radiotherapy. Resistance...