Dietary flavonoid intake and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort
Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development is still sparse and inconsistent. We evalu...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2016
|
| _version_ | 1797089125477646336 |
|---|---|
| author | Zamora-Ros, R Barupal, D Rothwell, J Jenab, M Fedirko, V Romieu, I Aleksandrova, K Overvad, K Kyrø, C Tjønneland, A Affret, A His, M Boutron-Ruault, M Katzke, V Kühn, T Boeing, H Trichopoulou, A Naska, A Kritikou, M Saieva, C Agnoli, C Santucci de Magistris, M Tumino, R Fasanelli, F Weiderpass, E Skeie, G Merino, S Jakszyn, P Sánchez, M Dorronsoro, M Navarro, C Ardanaz, E Sonestedt, E Ericson, U Nilsson, L Bodén, S Bueno-de-Mesquita, H Peeters, P Perez-Cornago, A Wareham, N Khaw, K Freisling, H Cross, A Riboli, E Scalbert, A |
| author_facet | Zamora-Ros, R Barupal, D Rothwell, J Jenab, M Fedirko, V Romieu, I Aleksandrova, K Overvad, K Kyrø, C Tjønneland, A Affret, A His, M Boutron-Ruault, M Katzke, V Kühn, T Boeing, H Trichopoulou, A Naska, A Kritikou, M Saieva, C Agnoli, C Santucci de Magistris, M Tumino, R Fasanelli, F Weiderpass, E Skeie, G Merino, S Jakszyn, P Sánchez, M Dorronsoro, M Navarro, C Ardanaz, E Sonestedt, E Ericson, U Nilsson, L Bodén, S Bueno-de-Mesquita, H Peeters, P Perez-Cornago, A Wareham, N Khaw, K Freisling, H Cross, A Riboli, E Scalbert, A |
| author_sort | Zamora-Ros, R |
| collection | OXFORD |
| description | Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development is still sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal=1,298 and distal=1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend=0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development. This article is protected by copyright. All rights reserved. |
| first_indexed | 2024-03-07T02:59:56Z |
| format | Journal article |
| id | oxford-uuid:b09d329b-2bf5-40dd-bb5b-0940bd2e3ba2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:59:56Z |
| publishDate | 2016 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:b09d329b-2bf5-40dd-bb5b-0940bd2e3ba22022-03-27T03:57:50ZDietary flavonoid intake and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) CohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b09d329b-2bf5-40dd-bb5b-0940bd2e3ba2EnglishSymplectic Elements at OxfordWiley2016Zamora-Ros, RBarupal, DRothwell, JJenab, MFedirko, VRomieu, IAleksandrova, KOvervad, KKyrø, CTjønneland, AAffret, AHis, MBoutron-Ruault, MKatzke, VKühn, TBoeing, HTrichopoulou, ANaska, AKritikou, MSaieva, CAgnoli, CSantucci de Magistris, MTumino, RFasanelli, FWeiderpass, ESkeie, GMerino, SJakszyn, PSánchez, MDorronsoro, MNavarro, CArdanaz, ESonestedt, EEricson, UNilsson, LBodén, SBueno-de-Mesquita, HPeeters, PPerez-Cornago, AWareham, NKhaw, KFreisling, HCross, ARiboli, EScalbert, AFlavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development is still sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal=1,298 and distal=1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend=0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development. This article is protected by copyright. All rights reserved. |
| spellingShingle | Zamora-Ros, R Barupal, D Rothwell, J Jenab, M Fedirko, V Romieu, I Aleksandrova, K Overvad, K Kyrø, C Tjønneland, A Affret, A His, M Boutron-Ruault, M Katzke, V Kühn, T Boeing, H Trichopoulou, A Naska, A Kritikou, M Saieva, C Agnoli, C Santucci de Magistris, M Tumino, R Fasanelli, F Weiderpass, E Skeie, G Merino, S Jakszyn, P Sánchez, M Dorronsoro, M Navarro, C Ardanaz, E Sonestedt, E Ericson, U Nilsson, L Bodén, S Bueno-de-Mesquita, H Peeters, P Perez-Cornago, A Wareham, N Khaw, K Freisling, H Cross, A Riboli, E Scalbert, A Dietary flavonoid intake and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort |
| title | Dietary flavonoid intake and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort |
| title_full | Dietary flavonoid intake and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort |
| title_fullStr | Dietary flavonoid intake and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort |
| title_full_unstemmed | Dietary flavonoid intake and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort |
| title_short | Dietary flavonoid intake and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort |
| title_sort | dietary flavonoid intake and colorectal cancer risk in the european prospective investigation into cancer and nutrition epic cohort |
| work_keys_str_mv | AT zamorarosr dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT barupald dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT rothwellj dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT jenabm dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT fedirkov dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT romieui dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT aleksandrovak dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT overvadk dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT kyrøc dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT tjønnelanda dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT affreta dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT hism dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT boutronruaultm dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT katzkev dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT kuhnt dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT boeingh dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT trichopouloua dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT naskaa dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT kritikoum dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT saievac dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT agnolic dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT santuccidemagistrism dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT tuminor dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT fasanellif dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT weiderpasse dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT skeieg dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT merinos dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT jakszynp dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT sanchezm dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT dorronsorom dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT navarroc dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT ardanaze dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT sonestedte dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT ericsonu dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT nilssonl dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT bodens dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT buenodemesquitah dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT peetersp dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT perezcornagoa dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT warehamn dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT khawk dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT freislingh dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT crossa dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT ribolie dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort AT scalberta dietaryflavonoidintakeandcolorectalcancerriskintheeuropeanprospectiveinvestigationintocancerandnutritionepiccohort |