Effect of immune pressure on hepatitis C virus evolution: Insights from a single-source outbreak

The host's immune response to hepatitis C virus (HCV) can result in the selection of characteristic mutations (adaptations) that enable the virus to escape this response. The ability of the virus to mutate at these sites is dependent on the incoming virus, the fitness cost incurred by the mutat...

Full description

Bibliographic Details
Main Authors: Merani, S, Petrovic, D, James, I, Chopra, A, Cooper, D, Freitas, E, Rauch, A, Di Iulio, J, John, M, Lucas, M, Fitzmaurice, K, Mckiernan, S, Norris, S, Kelleher, D, Klenerman, P, Gaudieri, S
Format: Journal article
Language:English
Published: 2011