Design of a molecular support for cryo-EM structure determination

Despite the recent rapid progress in cryo-electron microscopy (cryo-EM), there still exist ample opportunities for improvement in sample preparation. Macromolecular complexes may disassociate or adopt nonrandom orientations against the extended air.water interface that exists for a short time before...

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Bibliographic Details
Main Authors: Martin, T, Bharat, T, Joerger, A, Bai, X, Praetorius, F, Fersht, A, Dietz, H, Scheres, S
Format: Journal article
Published: National Academy of Sciences 2016