Effective suppression of HIV-1 replication by cytotoxic T lymphocytes specific for pol epitopes in conserved mosaic vaccine immunogens

Effective suppression of HIV-1 replication by cytotoxic T lymphocytes specific for pol epitopes in conserved mosaic vaccine immunogens

Cytotoxic T lymphocytes (CTLs) with strong abilities to suppress HIV-1 replication and recognize circulating HIV-1 could be key for both HIV-1 cure and prophylaxis. We recently designed conserved mosaic T-cell vaccine immunogens tHIVconsvX composed of 6 Gag and Pol regions. Since the tHIVconsvX vacc...

Full description

Bibliographic Details
Main Authors:	Zou, C, Murakoshi, H, Kuse, N, Akahoshi, T, Chikata, T, Gatanaga, H, Oka, S, Hanke, T, Takiguchi, M
Format:	Journal article
Language:	English
Published:	American Society for Microbiology 2019

Similar Items

Control of HIV-1 by CD8+T cells specific for epitopes of conserved mosaic vaccine immunogens
by: Murakoshi, H, et al.
Published: (2018)

CD8+ T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication
by: Murakoshi, H, et al.
Published: (2018)

Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 control
by: Murakoshi, H, et al.
Published: (2018)

Identification of immunodominant HIV-1 epitopes presented by 2 HLA-C*12:02, a protective allele, using an immunopeptidomics 3 approach
by: Chikata, T, et al.
Published: (2019)

The impact of HLA-Cw*12:02 on control of HIV-1 infection
by: Koyanagi M, et al.
Published: (2012-09-01)

P16-06. Control of HIV-1 by HIV-1 Pol-specific CD8+ T cells in chronically HIV-1-infected Japanese cohort
by: Takiguchi M, et al.
Published: (2009-10-01)

HIV-1 protective epitope-specific CD8+ T cells in HIV-1-exposed seronegative individuals
by: Takayuki Chikata, et al.
Published: (2023-11-01)

Impact of a single HLA-A*24:02-associated escape mutation on the detrimental effect of HLA-B*35:01 in HIV-1 controlResearch in Context
by: Hayato Murakoshi, et al.
Published: (2018-10-01)

T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics.
by: Tomohiro Akahoshi, et al.
Published: (2020-12-01)

Long-term memory CD8+ T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccine
by: Nozomi Kuse, et al.
Published: (2022-09-01)

Cross-clade CTL recognitions for clade B and A/E viruses in A/E virus-infected Japanese individuals
by: Watanabe K, et al.
Published: (2012-09-01)

Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
by: Frahm, N, et al.
Published: (2006)

Control of HIV-1 by multiple immunodominant HIV-1-specific CD8+ T cells in HIV-1-infected Japanese individuals
by: Murakoshi H, et al.
Published: (2012-09-01)

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.
by: Borthwick, N, et al.
Published: (2017)

Long-term control of HIV-1 in hemophiliacs carrying slow-progressing allele HLA-B*5101.
by: Kawashima, Y, et al.
Published: (2010)

Identification of novel HIV-1-derived HLA-E-binding peptides
by: Hannoun, Z, et al.
Published: (2018)

Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naïve HIV-Infected Individuals.
by: Juan Blanco-Heredia, et al.
Published: (2016-01-01)

Effect of epitope flanking residues on the presentation of N-terminal cytotoxic T lymphocyte epitopes.
by: Gileadi, U, et al.
Published: (1999)

CYTOTOXIC T-LYMPHOCYTE RECOGNITION OF HIV - EPITOPE SELECTION AND ESCAPE
by: Mcmichael, A, et al.
Published: (1993)

Correction: Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naïve HIV-Infected Individuals.
by: Juan Blanco-Heredia, et al.
Published: (2016-01-01)

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.
by: Nicola Borthwick, et al.
Published: (2017-01-01)

Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction
by: Lund Ole, et al.
Published: (2007-10-01)

Identification of cytotoxic T lymphocyte epitopes on swine viruses: multi-epitope design for universal T cell vaccine.
by: Yu-Chieh Liao, et al.
Published: (2013-01-01)

Conservation within cytotoxic T lymphocyte epitopes in hepatitis C virus in chronic infection.
by: Christie, J, et al.
Published: (1997)

Epitope Prediction Assays Combined with Validation Assays Strongly Narrows down Putative Cytotoxic T Lymphocyte Epitopes
by: Peng Peng Ip, et al.
Published: (2015-03-01)

Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins
by: Wu Shipo, et al.
Published: (2012-06-01)

P16-22. In impact of nadir CD4 counts on skewed distributions of functional subsets in peripheral CD4+ T cells in patients chronically infected with HIV-1
by: Takiguchi M, et al.
Published: (2009-10-01)

Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope.
by: Matthews, P, et al.
Published: (2012)

DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice.
by: Hanke, T, et al.
Published: (1998)

Comparative Immunogenicity of a Cytotoxic T Cell Epitope Delivered by Penetratin and TAT Cell Penetrating Peptides
by: Nicole Brooks, et al.
Published: (2015-08-01)

Cytotoxic T lymphocytes to Plasmodium falciparum epitopes in an area of intense and perennial transmission in Tanzania.
by: Lalvani, A, et al.
Published: (1996)

Cytotoxic T lymphocyte epitopes in hepatitis C virus identified with HLA assembly assays.
by: Healey, C, et al.
Published: (1996)

Immunodominance of cytotoxic T lymphocyte epitopes co-injected in vivo and modulation by interleukin-12.
by: Eberl, G, et al.
Published: (1996)

Impact of micropolymorphism outside the 1 peptide binding groove in the clinically-relevant allele HLA-C*14 on T cell responses in HIV-1 infection
by: Chikata, T, et al.
Published: (2022)

IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase.
by: Sewell, A, et al.
Published: (1999)

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides.
by: Townsend, A, et al.
Published: (1986)

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes.
by: Klenerman, P, et al.
Published: (1998)

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides
by: Townsend, A, et al.
Published: (1986)

Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope.
by: Goulder, P, et al.
Published: (2000)

Designing and testing broadly-protective filoviral vaccines optimized for cytotoxic T-lymphocyte epitope coverage.
by: Paul W Fenimore, et al.
Published: (2012-01-01)