Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients.

Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients.

HIV-1 samples from six patients undergoing diverse anti-HIV therapies possessed the E138A mutation in their reverse transcriptase (RT) genome. Patients were receiving the following therapies: TIBO monotherapy (one patient); zidovudine plus didanosine combination therapy (one); zidovudine monotherapy...

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Bibliographic Details
Main Authors: Van Laethem, K, Schmit, J, Pelemans, H, Balzarini, J, Witvrouw, M, Pérez-Pérez, M, Camarasa, M, Esnouf, R, Aquaro, S, Cenci, A, Perno, C, Hermans, P, Sprecher, S, Ruiz, L, Clotet, B, Van Wijngaerden, E, Van Ranst, M, Desmyter, J, De Clercq, E, Vandamme, A
Format: Journal article
Language:English
Published: 2000

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