beta-blocker binding to human 5-HT(1A) receptors in vivo and in vitro: implications for antidepressant therapy.

A novel strategy for improving the treatment of depressive illness is augmentation of antidepressants with a 5-HT1(1A) autoreceptor antagonist. However, trials using the 5-HT1(1A)/beta-blocker pindolol are proving inconsistent. We report how positron emission tomography (PET) and in vitro autoradiog...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Rabiner, E, Gunn, R, Castro, M, Sargent, P, Cowen, P, Koepp, M, Meyer, J, Bench, C, Harrison, P, Pazos, A, Sharp, T, Grasby, P
Format: Journal article
Sprache:English
Veröffentlicht: 2000