beta-blocker binding to human 5-HT(1A) receptors in vivo and in vitro: implications for antidepressant therapy.

A novel strategy for improving the treatment of depressive illness is augmentation of antidepressants with a 5-HT1(1A) autoreceptor antagonist. However, trials using the 5-HT1(1A)/beta-blocker pindolol are proving inconsistent. We report how positron emission tomography (PET) and in vitro autoradiog...

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Bibliografiske detaljer
Main Authors: Rabiner, E, Gunn, R, Castro, M, Sargent, P, Cowen, P, Koepp, M, Meyer, J, Bench, C, Harrison, P, Pazos, A, Sharp, T, Grasby, P
Format: Journal article
Sprog:English
Udgivet: 2000