Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39.
GPR39 is a G-protein-coupled zinc receptor that protects against diverse effectors of cell death. Its protective activity is mediated via constitutive activation of Gα13 and the RhoA pathway, leading to increased SRE (serum-response element)-dependent transcription; the zinc-dependent immediate acti...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Portland Press Ltd
2014
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