Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Hydroxylation of two conserved prolyl residues in the N- and C-terminal oxygen-dependent degradation domains (NODD and CODD) of the alpha-subunit of hypoxia-inducible factor (HIF) signals for its degradation via the ubiquitin-proteasome pathway. In human cells, three prolyl hydroxylases (PHDs 1-3) b...

書誌詳細
主要な著者:	Flashman, E, Bagg, E, Chowdhury, R, Mecinović, J, Loenarz, C, McDonough, M, Hewitson, K, Schofield, C
フォーマット:	Journal article
言語:	English
出版事項:	2008

類似資料

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
著者:: Chowdhury, R, 等
出版事項: (2009)

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
著者:: Mecinović, J, 等
出版事項: (2009)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
著者:: Chowdhury, R, 等
出版事項: (2011)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
著者:: Chowdhury, R, 等
出版事項: (2011)

Substrate selectivity of prolyl hydroxylases
著者:: McDonough, M
出版事項: (2018)

BIOL 56-ESI-MS studies on prolyl hydroxylase domain 2
著者:: Mecinovic, J, 等
出版事項: (2008)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
著者:: Abboud, M, 等
出版事項: (2018)

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.
著者:: Mecinović, J, 等
出版事項: (2009)

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases
著者:: Lippl, K, 等
出版事項: (2015)

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
著者:: McDonough, M, 等
出版事項: (2006)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
著者:: Hewitson, K, 等
出版事項: (2007)

Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture
著者:: Bush, J, 等
出版事項: (2018)

Mass spectrometric studies on an oxygen sensing prolyl hydroxylase
著者:: Mecinovic, J, 等
出版事項: (2007)

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
著者:: Flashman, E, 等
出版事項: (2010)

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
著者:: Flashman, E, 等
出版事項: (2010)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
著者:: Flashman, E, 等
出版事項: (2010)

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens
著者:: Lippl, K, 等
出版事項: (2018)

ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site.
著者:: Mecinović, J, 等
出版事項: (2008)

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.
著者:: McNeill, L, 等
出版事項: (2005)

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases
著者:: Horita, S, 等
出版事項: (2015)

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
著者:: Liu, T, 等
出版事項: (2020)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
著者:: Figg, WD, 等
出版事項: (2023)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
著者:: Figg, WD, 等
出版事項: (2021)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
著者:: Chowdhury, R, 等
出版事項: (2013)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
著者:: Conejo-Garcia, A, 等
出版事項: (2005)

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
著者:: Tarhonskaya, H, 等
出版事項: (2014)

2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
著者:: Abboud, M, 等
出版事項: (2018)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
著者:: Holt-Martyn, J, 等
出版事項: (2019)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
著者:: Mole, D, 等
出版事項: (2003)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
著者:: Chan, M, 等
出版事項: (2016)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
著者:: Lancaster, D, 等
出版事項: (2004)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
著者:: McNeill, L, 等
出版事項: (2002)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
著者:: Schlemminger, I, 等
出版事項: (2003)

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay.
著者:: Ehrismann, D, 等
出版事項: (2007)

Inhibition of a viral prolyl hydroxylase
著者:: Langley, G, 等
出版事項: (2019)

Mechanism of molecular oxygen diffusion in a hypoxia-sensing prolyl hydroxylase using multiscale simulation
著者:: Domene, C, 等
出版事項: (2020)

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
著者:: Li, Z, 等
出版事項: (2020)

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase, and is sensitive to off target inhibition by prolyl hydroxylase domain inhibitors that stabilise Hypoxia Inducible Factor
著者:: Kiriakidis, S, 等
出版事項: (2017)

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.
著者:: Stubbs, C, 等
出版事項: (2009)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
著者:: Astuti, D, 等
出版事項: (2010)