Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Hydroxylation of two conserved prolyl residues in the N- and C-terminal oxygen-dependent degradation domains (NODD and CODD) of the alpha-subunit of hypoxia-inducible factor (HIF) signals for its degradation via the ubiquitin-proteasome pathway. In human cells, three prolyl hydroxylases (PHDs 1-3) b...

Полное описание

Библиографические подробности
Главные авторы:	Flashman, E, Bagg, E, Chowdhury, R, Mecinović, J, Loenarz, C, McDonough, M, Hewitson, K, Schofield, C
Формат:	Journal article
Язык:	English
Опубликовано:	2008

Схожие документы

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
по: Chowdhury, R, и др.
Опубликовано: (2009)

2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
по: Mecinović, J, и др.
Опубликовано: (2009)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
по: Chowdhury, R, и др.
Опубликовано: (2011)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
по: Chowdhury, R, и др.
Опубликовано: (2011)

Substrate selectivity of prolyl hydroxylases
по: McDonough, M
Опубликовано: (2018)

BIOL 56-ESI-MS studies on prolyl hydroxylase domain 2
по: Mecinovic, J, и др.
Опубликовано: (2008)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
по: Abboud, M, и др.
Опубликовано: (2018)

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.
по: Mecinović, J, и др.
Опубликовано: (2009)

Exploring the substrate selectivity of oxygen sensing prolyl hydroxylases
по: Lippl, K, и др.
Опубликовано: (2015)

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
по: McDonough, M, и др.
Опубликовано: (2006)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
по: Hewitson, K, и др.
Опубликовано: (2007)

Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture
по: Bush, J, и др.
Опубликовано: (2018)

Mass spectrometric studies on an oxygen sensing prolyl hydroxylase
по: Mecinovic, J, и др.
Опубликовано: (2007)

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
по: Flashman, E, и др.
Опубликовано: (2010)

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
по: Flashman, E, и др.
Опубликовано: (2010)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
по: Flashman, E, и др.
Опубликовано: (2010)

Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens
по: Lippl, K, и др.
Опубликовано: (2018)

ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site.
по: Mecinović, J, и др.
Опубликовано: (2008)

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate.
по: McNeill, L, и др.
Опубликовано: (2005)

Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio- and stereoselectivity of prolyl hydroxylases
по: Horita, S, и др.
Опубликовано: (2015)

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
по: Liu, T, и др.
Опубликовано: (2020)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
по: Figg, WD, и др.
Опубликовано: (2023)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
по: Figg, WD, и др.
Опубликовано: (2021)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
по: Chowdhury, R, и др.
Опубликовано: (2013)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
по: Conejo-Garcia, A, и др.
Опубликовано: (2005)

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
по: Tarhonskaya, H, и др.
Опубликовано: (2014)

2-oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2
по: Abboud, M, и др.
Опубликовано: (2018)

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors
по: Holt-Martyn, J, и др.
Опубликовано: (2019)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
по: Mole, D, и др.
Опубликовано: (2003)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
по: Chan, M, и др.
Опубликовано: (2016)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
по: Lancaster, D, и др.
Опубликовано: (2004)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
по: McNeill, L, и др.
Опубликовано: (2002)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
по: Schlemminger, I, и др.
Опубликовано: (2003)

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay.
по: Ehrismann, D, и др.
Опубликовано: (2007)

Inhibition of a viral prolyl hydroxylase
по: Langley, G, и др.
Опубликовано: (2019)

Mechanism of molecular oxygen diffusion in a hypoxia-sensing prolyl hydroxylase using multiscale simulation
по: Domene, C, и др.
Опубликовано: (2020)

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation
по: Li, Z, и др.
Опубликовано: (2020)

Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase, and is sensitive to off target inhibition by prolyl hydroxylase domain inhibitors that stabilise Hypoxia Inducible Factor
по: Kiriakidis, S, и др.
Опубликовано: (2017)

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.
по: Stubbs, C, и др.
Опубликовано: (2009)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
по: Astuti, D, и др.
Опубликовано: (2010)