The reason for a high Ca2+-sensitivity associated with Arg91Gly substitution in TPM2 gene is the abnormal behavior and high flexibility of tropomyosin during the ATPase cycle

Substitution of Arg for Gly residue in 91th position in β-tropomyosin caused by a point mutation in TPM2 gene is associated with distal arthrogryposis, characterized by a high Ca2+-sensitivity of myofilament and contracture syndrome. To understand the mechanisms of this defect, we studied multistep...

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Bibliographic Details
Main Authors: Borovikov, Y, Simonyan, A, Karpicheva, O, Avrova, S, Rysev, N, Sirenko, V, Piers, A, Redwood, C
Format: Journal article
Language:English
Published: Elsevier 2017