Crystal structure of sialylated IgG Fc: implications for the mechanism of intravenous immunoglobulin therapy.
Intravenous Ig consists of pooled human serum IgG and is widely used as an antiinflammatory agent. The fraction of IgG that is α2,6-sialylated exhibits anti-inflammatory activity and sialylation is proposed to enable binding to the cell surface lectin, dendritic cell-specific intercellular adhesion...
| Huvudupphovsmän: | , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
National Academy of Sciences
2013
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