Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

Glucagon secretion is regulated by glucose but the mechanisms involved remain hotly debated. Both intrinsic (within the α-cell itself) and paracrine (mediated by factors released β- and/or δ-cells) have been postulated. Glucagon secretion is maximally suppressed by glucose concentrations that do not...

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Bibliographic Details
Main Authors: Walker, J, Ramracheya, R, Zhang, Q, Johnson, P, Braun, M, Rorsman, P
Format: Journal article
Language:English
Published: 2011