Methylation and Clonality of Human Colonic Crypts

Methylation and Clonality of Human Colonic Crypts

Bibliografische gegevens
Hoofdauteurs:	Graham, T, Humphries, A, McDonald, SA, Leedham, S, Wright, N
Formaat:	Conference item
Gepubliceerd in:	2009

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METHODS FOR TRACING CRYPT STEM CELLS ANCESTRY AND CLONAL ARCHITECTURE USING CPG ISLAND METHYLATION AND MITOCHONDRIAL DNA MUTATIONS
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HUMAN SMALL INTESTINAL CRYPTS ARE CLONAL, CONTAIN MULTIPLE STEM CELLS AND MUTATED CRYPTS DIVIDE BY FISSION
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Modelling of the expansion of normal human colonic crypts
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Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.
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Use of methylation patterns to determine expansion of stem cell clones in human colon tissue.
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Modelling the expansion of mutated clones within human colonic crypts and their migration through the colon
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Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.
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Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus.
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Clonal expansion in the human gut: mitochondrial DNA mutations show us the way.
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Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.
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Human tumour clonality assessment--flawed but necessary.
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The stem cell population of the human colon crypt: analysis via methylation patterns.
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The Clonal Origins of Dysplasia from Metaplasia in the Human Stomach
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The clonal origin of human tumours: is familial adenomatous polyposis (FAP) different?
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Using somatic APC mutations as clonal markers in colonic polyps
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Immunohistologic demonstration of abnormal colonic crypt cell kinetics in ulcerative colitis.
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Monoclonal conversion in human gastric glands gives insights into stem cell and clonal architecture
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THE CLONAL PROGRESSION OF BARRETT'S OESOPHAGUS TO OESOPHAGEAL ADENOCARCINOMA
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Using somatic APC mutations as clonal markers to demonstrate polyclonality in colonic polyps
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Tracing ancestry with methylation patterns: most crypts appear distantly related in normal adult human colon
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The fixation of mutations and clonal expansion in intestinal metaplasia: Field cancerisation in the human stomach
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Characteristics of the colonic crypts in inflammatory bowel diseases
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The clonal origins of dysplasia from intestinal metaplasia in the human stomach.
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Investigating Clonal Dynamics in Barrett's Associated tumorigenesis Using Spatial Maps of Genetic Heterogeneity
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Patterns of proliferative activity in the colonic crypt determine crypt stability and rates of somatic evolution.
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Mathematical modeling of monoclonal conversion in the colonic crypt
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Mathematical modeling of monoclonal conversion in the colonic crypt.
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Mapping clonality in individual glands in human Barrett's esophagus
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INVESTIGATING CLONAL COMPETITION IN BARRETT'S ASSOCIATED TUMORIGENESIS USING SPATIAL MAPS OF GENETIC HETEROGENEITY
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Early commitment and robust differentiation in colonic crypts
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Mapping clonality in individual glands from human Barrett's oesophagus
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Corrupted colonic crypt fission in carcinogen-treated rats.
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Field Cancerization in Crohn's Disease
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Crypt- and Mucosa-Associated Core Microbiotas in Humans and Their Alteration in Colon Cancer Patients
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A Model of Colonic Crypts using SBML Spatial
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Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations.
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Microfabricated Crypt Scaffolds: A New Foundation for Evaluating Human Colon Stem Cells
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The APC Network Regulates the Removal of Mutated Cells from Colonic Crypts
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Analysis of Complex Behavior of Stem Cell Populations in Colonic Crypts
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A Crypt-Specific Core Microbiota Resides in the Mouse Colon
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