The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data

The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data

Background: Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria, although treatment failures occur in some regions. We investigated the effect of dosing strategy on efficacy in a pooled analysis from trials done in a wide range of malaria-endemic setting...

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Main Authors: Anstey, N, Price, R, Davis, T, Karunajeewa, H, Mueller, I, D'Alessandro, U, Massougbodji, A, Nikiema, F, Ouedraogo, J, Tinto, H, Zongo, I, Same-Ekobo, A, Kone, M, Menan, H, Toure, A, Yavo, W, Kofoed, P, Alemayehu, B, Jima, D, Baudin, E, Espie, E, Nabasumba, C, Pinoges, L, Schramm, B, Cot, M, Deloron, P, Faucher, J, Guthmann, J, Lell, B, Borrmann, S, Adjei, G, Ursing, J, Tjitra, E, Marsh, K, Peshu, J, Juma, E, Ogutu, B, Omar, SA, Sawa, P, Talisuna, A, Khanthavong, M, Mayxay, M, Newton, P, Piola, P, Djimde, A, Doumbo, O, Fofana, B, Sagara, I, Bassat, Q, Gonzalez, R, Menendez, C, Smithuis, F, Bousema, T, Kager, P, Mens, P, Schallig, H, Van den Broek, I, Van Vugt, M, Ibrahim, M, Falade, C, Meremikwu, M, Gil, J, Karema, C, Ba, MS, Faye, B, Faye, O, Gaye, O, Ndiaye, J, Pene, M, Sow, D, Sylla, K, Tine, R, Penali, L, Barnes, K, Workman, L, Lima, A, Adam, I, Gadalla, N, Malik, E, Bjorkman, A, Martensson, A, Ngasala, B, Rombo, L, Aliu, P, Duparc, S, Filler, S, Genton, B, Hodel, E, Olliaro, P, Abdulla, S, Kamugisha, E, Premji, Z, Shekalaghe, SA, Ashley, E, Carrara, V, McGready, R, Nosten, F, Faiz, A, Lee, S, White, N, Dondorp, A, Smith, J, Tarning, J, Achan, J, Bukirwa, H, Yeka, A, Arinaitwe, E, Staedke, S, Kamya, MR, Kironde, F, Drakeley, C, Oguike, M, Sutherland, C, Checchi, F, Dahal, P, Flegg, J, Guerin, P, Moreira, C, Nsanzabana, C, Sibley, C, Stepniewska, K, Gething, P, Hay, S, Greenwood, B, Ward, SA, Winstanley, P, Dorsey, G, Greenhouse, B, Rosenthal, P, Grivoyannis, A, Hamed, K, Hwang, J, Kachur, P, Nambozi, M, Resistance, W
Format: Journal article
Published: Elsevier 2015

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