Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene
The 85-kb breast cancer-associated gene BRCA1 is an established tumor suppressor gene, but its regulation is poorly understood. We demonstrate by gene conformation analysis in both human cell lines and mouse mammary tissue that gene loops are imposed on BRCA1 between the promoter, introns, and termi...
| Main Authors: | , , , |
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| Format: | Journal article |
| Published: |
National Academy of Sciences
2008
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