Modelling perspectives on the intestinal crypt, a canonical system for growth, mechanics and remodelling
The intestinal epithelium is crucial to maintaining a healthy gut. Central to this are the crypts of Lieberkühn, which coordinate the rapid self-renewal of the epithelium to protect the small intestine and colon during digestion. Further, mutations in crypt cells may initiate colorectal cancer. It i...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2020
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| _version_ | 1826292030862524416 |
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| author | Almet, A Maini, P Moulton, D Byrne, H |
| author_facet | Almet, A Maini, P Moulton, D Byrne, H |
| author_sort | Almet, A |
| collection | OXFORD |
| description | The intestinal epithelium is crucial to maintaining a healthy gut. Central to this are the crypts of Lieberkühn, which coordinate the rapid self-renewal of the epithelium to protect the small intestine and colon during digestion. Further, mutations in crypt cells may initiate colorectal cancer. It is, therefore, important to understand how crypts function during homeostasis and disease. Mathematical and computational modelling has contributed to increasing our understanding of crypt dynamics. However, many open questions remain to be addressed, particularly regarding the role of mechanics in intestinal crypt dynamics. In this article, we review the state-of-the-art in crypt modelling and explain why further progress requires integration of new theory from continuum mechanics with cell-based computational models and experimental data. |
| first_indexed | 2024-03-07T03:08:26Z |
| format | Journal article |
| id | oxford-uuid:b35d297f-04ca-4d52-8b8b-8aa29e152564 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T03:08:26Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:b35d297f-04ca-4d52-8b8b-8aa29e1525642022-03-27T04:18:29ZModelling perspectives on the intestinal crypt, a canonical system for growth, mechanics and remodellingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:b35d297f-04ca-4d52-8b8b-8aa29e152564EnglishSymplectic ElementsElsevier2020Almet, AMaini, PMoulton, DByrne, HThe intestinal epithelium is crucial to maintaining a healthy gut. Central to this are the crypts of Lieberkühn, which coordinate the rapid self-renewal of the epithelium to protect the small intestine and colon during digestion. Further, mutations in crypt cells may initiate colorectal cancer. It is, therefore, important to understand how crypts function during homeostasis and disease. Mathematical and computational modelling has contributed to increasing our understanding of crypt dynamics. However, many open questions remain to be addressed, particularly regarding the role of mechanics in intestinal crypt dynamics. In this article, we review the state-of-the-art in crypt modelling and explain why further progress requires integration of new theory from continuum mechanics with cell-based computational models and experimental data. |
| spellingShingle | Almet, A Maini, P Moulton, D Byrne, H Modelling perspectives on the intestinal crypt, a canonical system for growth, mechanics and remodelling |
| title | Modelling perspectives on the intestinal crypt, a canonical system for growth, mechanics and remodelling |
| title_full | Modelling perspectives on the intestinal crypt, a canonical system for growth, mechanics and remodelling |
| title_fullStr | Modelling perspectives on the intestinal crypt, a canonical system for growth, mechanics and remodelling |
| title_full_unstemmed | Modelling perspectives on the intestinal crypt, a canonical system for growth, mechanics and remodelling |
| title_short | Modelling perspectives on the intestinal crypt, a canonical system for growth, mechanics and remodelling |
| title_sort | modelling perspectives on the intestinal crypt a canonical system for growth mechanics and remodelling |
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