Inotropic actions of protein kinase C activation by phorbol dibutyrate in guinea-pig isolated ventricular myocytes.

The mechanisms which underlie the inotropic actions of phorbol dibutyrate (PDBu), a synthetic compound which can directly activate protein kinase C (PKC), were investigated in guinea-pig isolated ventricular myocytes. Exposure of cells to PDBu (10(-7) M) reduced myocyte contraction amplitude to 46 +...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính: Mamas, M, Terrar, D
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2001