Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.

Two isozymes of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) interconvert active cortisol and inactive cortisone. 11 beta-HSD2 (renal) acts only as a dehydrogenase, converting cortisol to cortisone. 11 beta-HSD1 (liver) is a bi-directional enzyme in cell homogenates, whereas in intact cells it...

Full description

Bibliographic Details
Main Authors: Bujalska, I, Draper, N, Michailidou, Z, Tomlinson, J, White, P, Chapman, K, Walker, E, Stewart, P
Format: Journal article
Language:English
Published: 2005