Transcription-dependent DNA double-strand breaks and human disease

Transcription-dependent DNA double-strand breaks and human disease

Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoi...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Cristini, A, Gromak, N, Sordet, O
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	Taylor and Francis 2020

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