Metabolic regulation of insulin secretion in health and disease

Metabolic regulation of insulin secretion in health and disease

Despite the current media focus, Covid-19 is not the only current pandemic. There is also a global pandemic of diabetes. It is caused by an insufficiency of the hormone insulin, which lowers blood glucose levels. Here we highlight recent work that addresses the question of how insulin is normally se...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Haythorne, E, Ashcroft, FM
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Portland Press 2021

Eitemau Tebyg

KATP channels and the metabolic regulation of insulin secretion in health and disease: the 2022 Banting Medal for Scientific Achievement Award Lecture
gan: Ashcroft, FM
Cyhoeddwyd: (2023)

The KCNJ11-E23K gene variant hastens diabetes progression by impairing glucose-induced insulin secretion
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Cyhoeddwyd: (2021)

K(ATP) channels and insulin secretion: a key role in health and disease.
gan: Ashcroft, F
Cyhoeddwyd: (2006)

ATP-sensitive K+ channels and insulin secretion: their role in health and disease.
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Cyhoeddwyd: (1999)

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.
gan: Zehetner, J, et al.
Cyhoeddwyd: (2008)

Glucokinase activity in diabetes: too much of a good thing?
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Cyhoeddwyd: (2022)

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ATP-sensitive potassium channelopathies: focus on insulin secretion.
gan: Ashcroft, F
Cyhoeddwyd: (2005)

Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress.
gan: Freeman, H, et al.
Cyhoeddwyd: (2006)

Molecular defects in insulin secretion in type-2 diabetes.
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Cyhoeddwyd: (2004)

Autocrine regulation of insulin secretion.
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Cyhoeddwyd: (2012)

Drosophila adiponectin receptor in insulin producing cells regulates glucose and lipid metabolism by controlling insulin secretion.
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Cyhoeddwyd: (2013-01-01)

Pancreatic β-cell electrical activity and insulin secretion: of mice and men
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Cyhoeddwyd: (2017)

ATP-SENSITIVE K-CHANNELS IN HIT-T15 INSULIN SECRETING CELLS
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Calcium currents in insulin-secreting beta-cells.
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Cyhoeddwyd: (1989)

Calcium currents in insulin-secreting beta-cells.
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Cyhoeddwyd: (1989)

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Cyhoeddwyd: (2006)

Amantadine and sparteine inhibit ATP-regulated K-currents in the insulin-secreting beta-cell line, HIT-T15.
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Cyhoeddwyd: (1991)

Metabolomics data for: Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells
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The role of nicotinamide nucleotide transhydrogenase in insulin secretion and impaired glucose tolerance
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Cyhoeddwyd: (2005)

Does Nicotinamide nucleotide transhydrogenase have a role in insulin secretion?
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Cyhoeddwyd: (2005)

Mitochondrial Carriers Regulating Insulin Secretion Profiled in Human Islets upon Metabolic Stress
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Ca(2+)-activated K+ channels from an insulin-secreting cell line incorporated into planar lipid bilayers.
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Cyhoeddwyd: (1992)

Ca2+-activated K+ channels from an insulin-secreting cell line incorporated into planar lipid bilayers
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Cyhoeddwyd: (1992)

Dysregulation of glucagon secretion by hyperglycemia-induced sodium-dependent reduction of ATP production
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Cyhoeddwyd: (2018)

Regulation of insulin secretion in human pancreatic islets.
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Cyhoeddwyd: (2013)

Regulation of insulin secretion by the post-translational modifications
gan: Chunhua Yang, et al.
Cyhoeddwyd: (2023-08-01)

What Is the Metabolic Amplification of Insulin Secretion and Is It (Still) Relevant?
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Cyhoeddwyd: (2021-06-01)

Chronic d-serine supplementation impairs insulin secretion
gan: Lisa Suwandhi, et al.
Cyhoeddwyd: (2018-10-01)

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport
gan: Nadeeja Wijesekara, et al.
Cyhoeddwyd: (2021-07-01)

Peeling the onion: another layer in the regulation of insulin secretion
gan: Kristie I. Aamodt, et al.
Cyhoeddwyd: (2023-04-01)

A role for glutamate transporters in the regulation of insulin secretion.
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Cyhoeddwyd: (2011-01-01)

Correction to: Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?
gan: James Cantley, et al.
Cyhoeddwyd: (2019-04-01)

Posttranscriptional Regulation of Insulin Resistance: Implications for Metabolic Diseases
gan: Ana Pérez-García, et al.
Cyhoeddwyd: (2022-01-01)

MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion.
gan: Marco Gallo, et al.
Cyhoeddwyd: (2011-03-01)

Insulin prevents counter-regulatory glucagon secretion by stimulation of somatostatin release
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Cyhoeddwyd: (2013)

Low extracellular magnesium does not impair glucose-stimulated insulin secretion.
gan: Lisanne M M Gommers, et al.
Cyhoeddwyd: (2019-01-01)

Binding of sulphonylureas to plasma proteins – a KATP channel perspective
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Cyhoeddwyd: (2018)

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion
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Cyhoeddwyd: (2020-04-01)

Cardiac‐Secreted Factors as Peripheral Metabolic Regulators and Potential Disease Biomarkers
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Cyhoeddwyd: (2016-06-01)