LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.

LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.

Mutations in leucine-rich repeat kinase 2 (LRRK2) lead to late-onset, autosomal dominant Parkinson's disease, characterized by the degeneration of dopamine neurons of the substantia nigra pars compacta, a deficit in dopamine neurotransmission and the development of motor and non-motor symptoms....

Full description

Bibliographic Details
Main Authors: Sloan, M, Alegre-Abarrategui, J, Potgieter, D, Kaufmann, A, Exley, R, Deltheil, T, Threlfell, S, Connor-Robson, N, Brimblecombe, K, Wallings, R, Cioroch, M, Bannerman, D, Bolam, J, Magill, P, Cragg, S, Dodson, P, Wade-Martins, R
Format: Journal article
Language:English
Published: Oxford University Press 2016

Similar Items