Cholesterol depletion of hepatoma cells impairs hepatitis B virus envelopment by altering the topology of the large envelope protein

Previous reports have shown that cholesterol depletion of the membrane envelope of the hepatitis B virus (HBV) impairs viral infection of target cells. A potential function of this lipid in later steps of the viral life cycle remained controversial, with secretion of virions and subviral particles (...

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Bibliographic Details
Main Authors: Dorobantu, C, Macovei, A, Lazar, C, Dwek, R, Zitzmann, N, Branza-Nichita, N
Format: Journal article
Language:English
Published: American Society for Microbiology 2011