Mechanistic studies of the folding of human lysozyme and the origin of amyloidogenic behavior in its disease-related variants.
The unfolding and refolding properties of human lysozyme and two amyloidogenic variants (Ile56Thr and Asp67His) have been studied by stopped-flow fluorescence and hydrogen exchange pulse labeling coupled with mass spectrometry. The unfolding of each protein in 5.4 M guanidine hydrochloride (GuHCl) i...
Main Authors: | , , , , , , |
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Format: | Journal article |
Language: | English |
Published: |
1999
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