Unbiased single cell spatial analysis localises inflammatory clusters of immature neutrophils-CD8 T cells to alveolar progenitor cells in fatal COVID-19 lungs

Single cell spatial interrogation of the immune-structural interactions in COVID -19 lungs is challenging, mainly because of the marked cellular infiltrate and architecturally distorted microstructure. To address this, we developed a suite of mathematical tools to search for statistically significan...

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Bibliographic Details
Main Authors:	COSMIC – COVID-19 Lung Single Cell Mass Cytometry Imaging Consortium STUDY, Weeratunga, P, Denney, L, Bull, J, Repapi, E, Sergeant, M, Etherington, R, Vuppussetty, C, Turner, GDH, Clelland, C, Cross, A, Issa, F, de Andrea, CE, Bermejo, IM, Sims, D, McGowan, S, Zurke, Y-X, Ahern, D, Gamez, E, Whalley, J, Richards, D, Klenerman, P, Monaco, C, Udalova, IA, Dong, T, Ogg, G, Knight, J, Byrne, H, Taylor, S, Ho, L-P
Format:	Internet publication
Language:	English
Published:	2022

Unbiased single cell spatial analysis localises inflammatory clusters of immature neutrophils-CD8 T cells to alveolar progenitor cells in fatal COVID-19 lungs

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