Drosophila Sas-6, Ana2 and Sas-4 self-organise into macromolecular structures that can be used to probe centriole and centrosome assembly

Centriole assembly requires a small number of conserved proteins. The precise pathway of centriole assembly has been difficult to study, as the lack of any one of the core assembly proteins [Plk4, Ana2 (the homologue of mammalian STIL), Sas-6, Sas-4 (mammalian CPAP) or Asl (mammalian Cep152)] leads...

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Bibliographic Details
Main Authors: Gartenmann, L, Vicente, CC, Wainman, A, Novak, ZA, Sieber, B, Richens, JH, Raff, JW
Format: Journal article
Language:English
Published: Company of Biologists 2020