Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.

Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.

Substrate specificity: Biochemical and crystallographic analyses reveal the hypoxia-inducible factor hydroxylase (FIH) as being promiscuous with respect to the residues that it can hydroxylate in β-position, which in addition to Asn, Asp, and His include Leu and Ser residues. The Ser substrate is ox...

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Bibliografiske detaljer
Main Authors:	Yang, M, Hardy, A, Chowdhury, R, Loik, N, Scotti, J, McCullagh, J, Claridge, T, McDonough, M, Ge, W, Schofield, C
Format:	Journal article
Sprog:	English
Udgivet:	2013

Lignende værker

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
af: Tarhonskaya, H, et al.
Udgivet: (2014)

Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
af: Lancaster, D, et al.
Udgivet: (2004)

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.
af: Lancaster, D, et al.
Udgivet: (2004)

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.
af: Yang, M, et al.
Udgivet: (2011)

Selective inhibition of factor inhibiting hypoxia-inducible factor.
af: McDonough, M, et al.
Udgivet: (2005)

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.
af: Yang, M, et al.
Udgivet: (2011)

Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: a potential hypoxia response modulating strategy
af: Wu, Y, et al.
Udgivet: (2021)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
af: Conejo-Garcia, A, et al.
Udgivet: (2005)

Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6
af: Mantri, M, et al.
Udgivet: (2012)

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.
af: Banerji, B, et al.
Udgivet: (2005)

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
af: Conejo-Garcia, A, et al.
Udgivet: (2010)

The 2-oxoglutarate-dependent oxygenase JMJD6 catalyses oxidation of lysine residues to give 5S-hydroxylysine residues.
af: Mantri, M, et al.
Udgivet: (2011)

Comparison of the substrate selectivity and biochemical properties of human and bacterial γ-butyrobetaine hydroxylase.
af: Rydzik, A, et al.
Udgivet: (2014)

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.
af: Conejo-Garcia, A, et al.
Udgivet: (2010)

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
af: Flashman, E, et al.
Udgivet: (2008)

Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
af: Abboud, M, et al.
Udgivet: (2018)

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
af: Chowdhury, R, et al.
Udgivet: (2009)

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
af: Hewitson, K, et al.
Udgivet: (2008)

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
af: Coleman, M, et al.
Udgivet: (2007)

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.
af: Hewitson, K, et al.
Udgivet: (2007)

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
af: Liu, T, et al.
Udgivet: (2020)

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
af: Pollard, P, et al.
Udgivet: (2008)

Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2
af: Figg, WD, et al.
Udgivet: (2023)

Substrate selectivity of prolyl hydroxylases
af: McDonough, M
Udgivet: (2018)

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases.
af: Aik, W, et al.
Udgivet: (2012)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
af: Chowdhury, R, et al.
Udgivet: (2011)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
af: Chowdhury, R, et al.
Udgivet: (2011)

New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria.
af: McDonough, M, et al.
Udgivet: (2003)

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.
af: Tarhonskaya, H, et al.
Udgivet: (2014)

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
af: Cockman, M, et al.
Udgivet: (2006)

Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications
af: Hsu, K-F, et al.
Udgivet: (2020)

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.
af: Scotti, J, et al.
Udgivet: (2014)

Inhibition of JMJD6 by 2-oxoglutarate mimics
af: Islam, MS, et al.
Udgivet: (2021)

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.
af: Islam, MS, et al.
Udgivet: (2019)

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
af: McDonough, M, et al.
Udgivet: (2006)

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803.
af: McNeill, L, et al.
Udgivet: (2002)

Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications
af: Kuo-Feng Hsu, et al.
Udgivet: (2021-01-01)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
af: Chowdhury, R, et al.
Udgivet: (2013)

Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes
af: Kaur, S, et al.
Udgivet: (2022)

Inhibition of 2-oxoglutarate dependent oxygenases.
af: Rose, N, et al.
Udgivet: (2011)