Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.

Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.

Substrate specificity: Biochemical and crystallographic analyses reveal the hypoxia-inducible factor hydroxylase (FIH) as being promiscuous with respect to the residues that it can hydroxylate in β-position, which in addition to Asn, Asp, and His include Leu and Ser residues. The Ser substrate is ox...

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Bibliographische Detailangaben
Hauptverfasser:	Yang, M, Hardy, A, Chowdhury, R, Loik, N, Scotti, J, McCullagh, J, Claridge, T, McDonough, M, Ge, W, Schofield, C
Format:	Journal article
Sprache:	English
Veröffentlicht:	2013

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