Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.

Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.

Substrate specificity: Biochemical and crystallographic analyses reveal the hypoxia-inducible factor hydroxylase (FIH) as being promiscuous with respect to the residues that it can hydroxylate in β-position, which in addition to Asn, Asp, and His include Leu and Ser residues. The Ser substrate is ox...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Yang, M, Hardy, A, Chowdhury, R, Loik, N, Scotti, J, McCullagh, J, Claridge, T, McDonough, M, Ge, W, Schofield, C
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2013

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Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen.
ανά: Tarhonskaya, H, κ.ά.
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Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases.
ανά: Lancaster, D, κ.ά.
Έκδοση: (2004)

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.
ανά: Lancaster, D, κ.ά.
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ανά: Yang, M, κ.ά.
Έκδοση: (2011)

Selective inhibition of factor inhibiting hypoxia-inducible factor.
ανά: McDonough, M, κ.ά.
Έκδοση: (2005)

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.
ανά: Yang, M, κ.ά.
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Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: a potential hypoxia response modulating strategy
ανά: Wu, Y, κ.ά.
Έκδοση: (2021)

Inhibition of hypoxia inducible factor (HIF) hydroxylases
ανά: Conejo-Garcia, A, κ.ά.
Έκδοση: (2005)

Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6
ανά: Mantri, M, κ.ά.
Έκδοση: (2012)

The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.
ανά: Banerji, B, κ.ά.
Έκδοση: (2005)

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor
ανά: Conejo-Garcia, A, κ.ά.
Έκδοση: (2010)

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ανά: Mantri, M, κ.ά.
Έκδοση: (2011)

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ανά: Rydzik, A, κ.ά.
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ανά: Conejo-Garcia, A, κ.ά.
Έκδοση: (2010)

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
ανά: Flashman, E, κ.ά.
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Studies on the substrate selectivity of the hypoxia-inducible factor prolyl hydroxylase 2 catalytic domain
ανά: Abboud, M, κ.ά.
Έκδοση: (2018)

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
ανά: Chowdhury, R, κ.ά.
Έκδοση: (2009)

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
ανά: Hewitson, K, κ.ά.
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ανά: Coleman, M, κ.ά.
Έκδοση: (2007)

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ανά: Hewitson, K, κ.ά.
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ανά: Liu, T, κ.ά.
Έκδοση: (2020)

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ανά: Pollard, P, κ.ά.
Έκδοση: (2008)

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ανά: Figg, WD, κ.ά.
Έκδοση: (2023)

Substrate selectivity of prolyl hydroxylases
ανά: McDonough, M
Έκδοση: (2018)

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases.
ανά: Aik, W, κ.ά.
Έκδοση: (2012)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)
ανά: Chowdhury, R, κ.ά.
Έκδοση: (2011)

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
ανά: Chowdhury, R, κ.ά.
Έκδοση: (2011)

New structural insights into the inhibition of serine proteases by cyclic peptides from bacteria.
ανά: McDonough, M, κ.ά.
Έκδοση: (2003)

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.
ανά: Tarhonskaya, H, κ.ά.
Έκδοση: (2014)

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).
ανά: Cockman, M, κ.ά.
Έκδοση: (2006)

Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications
ανά: Hsu, K-F, κ.ά.
Έκδοση: (2020)

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation.
ανά: Scotti, J, κ.ά.
Έκδοση: (2014)

Inhibition of JMJD6 by 2-oxoglutarate mimics
ανά: Islam, MS, κ.ά.
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Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6.
ανά: Islam, MS, κ.ά.
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ανά: McDonough, M, κ.ά.
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ανά: McNeill, L, κ.ά.
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Inhibition of 2-oxoglutarate dependent oxygenases.
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